Horrified by the new girlfriends of their respective sons, three sisters-in-law – Clara (Consuelo Duval), a socialite, Matis (Mónica Huarte), a widowed professional, and Nena (del Castillo), a naive housewife – make an alliance to get rid of their undesirable daughters-in-law. It’s for their own good.

Based on the book by Benjamin Alire Sáenz, set in 1987 El Paso, it's the tale of two teenage Mexican-American loners as they explore their friendship and the difficult road to self-discovery.

Maggie is in her last days of pregnancy, but she and her husband Sean are attacked in their isolated home by two people who decide to wait with them until Monday to empty the family's bank accounts. The couple is willing to give them what they ask for, as long as they allow them to go to the hospital. But the thieves have other plans, and with the baby will come revelations that they would never have expected.

Eighteen-year-old aspiring comic Joey just found out his boyfriend has been cheating on him for the past ten months. But what did he expect? Joey was born with an addiction to toxic jerks—something he inherited from his lovably messy, wisecracking, Cuban-American spitfire of a mom (and best friend): 34-year-old Gia. When Gia’s latest non-relationship goes up in flames, the pair’s Bayonne, New Jersey apartment can barely contain their rage. In a misguided attempt at revenge, Joey and Gia inadvertently commit a series of crimes and flee the state, running to the only good man either of them has ever known—Gia’s ex, Marco.